Institute of Transplantation Diagnostics and Cell Therapeutics (ITZ)

Lectures, Practical Courses, Conferences
Contact / Head

Personal Data

Name:                    Dr. rer. nat. Simeon Santourlidis

Date of birth:       May 4, 1965

Place of birth:      Neuss, Germany

Citizenship:           German

Address:                 Institute for Transplantation Diagnostics and Cell Therapeutics
                                  Heinrich-Heine University Düsseldorf
                                  Moorenstrasse 5, Bldg. 14.80, 40225 Düsseldorf
                                  Phone: +49-211 81 16905 / Fax: +49-211 81 19429

Private address:   Venloerstrasse 39, 41462 Neuss


1996                         M. Sc. in Biology, University of Düsseldorf, Germany

2000                         Ph. D. in Biology, University of Düsseldorf, Germany


1995-1996              M. Sc. Thesis at Institute for Molecular Parasitology of the
                                   Heinrich-Heine-University Düsseldorf, Germany (Head: Prof. W.

1997 - 2000            Ph. D. Thesis at Department for Molecular Urology (Prof. W.A.
                                   Schulz) of Clinic of Urology ( Prof. R. Ackermann),
                                   Heinrich-Heine University Düsseldorf, Germany

2000 - 2008            Post-doctoral Fellow at the Young Investigator Group ‘Function
                                   of Natural Killer Cells’ (Prof. M. Uhrberg)
                                   Heinrich-Heine University Düsseldorf, Germany

Since 2008              Head of Epigenetics Core Laboratory at Institute for
                                   Transplantation Diagnostics and Cell Therapeutics,
                                   Heinrich-Heine University Düsseldorf, Germany

Publications (1999-2009)

1:         Santourlidis S, Graffmann N, Christ J, Uhrberg M. Lineage-specific transition of
             histone signatures in the killer cell Ig-like receptor locus from hematopoietic
             progenitor to NK cells. J Immunol 2008.

2:         Edgar Grinstein, Yihua Du, Simeon Santourlidis, Julia christ, Markus Uhrberg and
             Peter Wernet. Nucleolin regulating gene expression in CD34 positive
             hematopoietic cells. J Biol Chem 2007.

3:         Graffmann N, Santourlidis S, Christ J, Wernet P, Uhrberg M. Direct and quantitative
             analysis of chromatin accessibility by MIRECAL--a Micrococcus nuclease/real-
             time PCR chromatin accessibility assay with locus specificity. Anal Biochem

4:         Trundley AE, Hiby SE, Chang C, Sharkey AM, Santourlidis S, Uhrberg M, Trowsdale
             J, Moffett A. Molecular characterization of KIR3DL3. Immunogenetics 2006.

5:         Hans-Ingo Trompeter, Natalia Gomez-Lozano, Simeon Santourlidis, Britta Eisermann,
             Peter Wernet, Carlos Vilches, and Markus Uhrberg. Three Structurally and
             Functionally Divergent Kinds of Promoters Regulate Expression of Clonally
             Distributed Killer Cell Ig-Like Receptors (KIR), of KIR2DL4, and of KIR3DL3. J
             Immunol 2005.

6:         Santourlidis S, Kimura F, Fischer J, Schulz WA. Suppression of clonogenicity by
             mammalian Dnmt1 mediated by the PCNA-binding domain. Biochem Cell Biol

7:         Stallmach A, Wittig BM, Kremp K, Goebel R, Santourlidis S, Zeitz M, Menges M,
             Raedle J, Zeuzem S, Schulz WA. Downregulation of CD44v6 in colorectal
             carcinomas is associated with hypermethylation of the CD44 promoter region.
             Exp Mol Pathol 2003.

8:         Kimura F, Seifert HH, Florl AR, Santourlidis S, Steinhoff C, Swiatkowski S, Mahotka
             C,Gerharz CD, Schulz WA. Decrease of DNA methyltransferase 1 expression
             relative to cell proliferation in transitional cell carcinoma. Int J Cancer 2003.

9:         Santourlidis S, Trompeter HI, Weinhold S, Eisermann B, Meyer KL, Wernet P,
             Uhrberg M. Crucial role of DNA methylation in determination of clonally
             distributed killer cell Ig-like receptor expression patterns in NK cells. J Immunol

10:       Schulz WA, Elo JP, Florl AR, Pennanen S, Santourlidis S, Engers R, Buchardt M,
             Seifert HH, Visakorpi T. Genomewide DNA hypomethylation is associated with
             alterations on chromosome 8 in prostate carcinoma. Genes Chromosomes
             Cancer 2002.

11:       Leube B, Drechsler M, Muhlmann K, Schafer R, Schulz WA, Santourlidis S,
             Anastasiadis A, Ackermann R, Visakorpi T, Muller W, Royer-Pokora B. Refined
             mapping of allele loss at chromosome 10q23-26 in prostate cancer. Prostate

12:       Santourlidis S, Warskulat U, Florl AR, Maas S, Pulte T, Fischer J, Muller W, Schulz
             WA. Hypermethylation of the tumor necrosis factor receptor superfamily 6
             (APT1, Fas, CD95/Apo-1)gene promoter at rel/nuclear factor kappaB sites in
             prostatic carcinoma. Mol Carcinog 2001.

13:       Santourlidis S, Florl A, Ackermann R, Wirtz HC, Schulz WA. High frequency of
             alterations in DNA methylation in adenocarcinoma of the prostate. Prostate

14:       Aguiar J, Santurlidis S, Nowok J, Alexander C, Rudnicki D, Gispert S, Schulz W,
             Auburger G. Identification of the physiological promoter for spinocerebellar
             ataxia 2 gene reveals a CpG island for promoter activity situated into the exon 1
             of this gene and provides data about the origin of the nonmethylated state of
             these types of islands. Biochem Biophys Res Commun 1999.